Abstract Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is essentially an adaptive immunity weapon in prokaryotes against foreign DNA. This system inspires the development of genome-editing technology in eukaryotes. In biomedicine research. CRISPR has offered a powerful platform to establish tumor-bearing models and screen potent... https://www.rawafricaonline.com/