WHO rules mandate that sterility test isolators undergo in depth revalidation at least annually, or maybe more commonly if important changes or servicing functions have occurred. Glove ports are positioned ergonomically and are validated with leak/penetration tests. VHP programs are integrated with cycle parameters logged and biologic indicator (BI) https://tailinscitech.weebly.com/blog/applications-and-benefits-of-tailin-containment-isolator-for-handling-high-potency-materials